화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.135, No.19, 7126-7129, 2013
Catalytic Enantioselective Carbon Insertion into the beta-Vinyl C-H Bond of Cyclic Enones
Chiral oxazaborolidinium ion-catalyzed C-sp(2)-H functionalization of enones using diazoacetate has been developed. Various beta-substituted cyclic enones were synthesized in high yield (up to 99%) with high to excellent enantioselectivity (up to 99% ee). The synthetic utility of this reaction was demonstrated by the formal synthesis of (+)-epijuvabione.