화학공학소재연구정보센터
Journal of the Korean Industrial and Engineering Chemistry, Vol.2, No.2, 87-96, June, 1991
약물방출 조절 시스템의 현황
Controlled Drug Delivery System
초록
지난 20년 동안에 약물방출시스템에 관한 연구가 활발히 진행되고 있다. 본고에서는 약물방출조절시스템을 약물방출메카니즘에 의해서 구분하고 이를 통한 약물방출거동에 대해서 논하였다. 또한 현재 약물방출조절시스템의 현황에 대해서 투여경로를 중심으로 구분하여 소개하였다.
Controlled drug Delivery systems have been actively studied for the past twenty years. In the present article controlled drug delivery system was classified by the delivery mechanism and the drug delivery behavior was discussed. Also overall status of drug delivery system was introduced through the route of drug adiministration.
  1. Zattaroni A, Chemtech, 757 (1980)
  2. Zattaroni A, Chemtech, 82 (1976)
  3. Chandra-Sekaran SK, Capozza R, Wong PSL, J. Membr. Sci., 3, 271 (1978) 
  4. Langer R, Chemtech, 98 (1982)
  5. Yolles SJ, Schimitt EEY, Polym. News, 1, 9 (1970)
  6. Kulkarni RK, Moose EG, Hegyeli AF, Leonard F, J. Biomed. Mater. Res., 5, 169 (1971)
  7. Frazza EJ, Schmitt EE, J. Biomed. Mater. Res., 1, 43 (1971) 
  8. Sidman KR, Schwape AD, Steber WD, Rudolph SE, Poulin SB, Polym. Prepr., 20(2), 27 (1979)
  9. Choi HS, Heller J, U.S. Patent, 4,093,709 (1978)
  10. Choi HS, Heller J, U.S. Patent, 4,131,648 (1978)
  11. Choi HS, Heller J, U.S. Patent, 4,138,344 (1979)
  12. Choi HS, Heller J, U.S. Patent, 4,180,646 (1979)
  13. Heller J, Biomaterials, 1, 51 (1980) 
  14. Lee PI, J. Membr. Sci., 7, 255 (1980) 
  15. Lee PI, J. Control. Release, 4, 1 (1986) 
  16. Duncan R, Kopecek J, Adv. Polym. Sci., 57, 51 (1983)
  17. Solovski MV, Ulbrich K, Kopecek J, Biomaterials, 4, 44 (1983) 
  18. Duncan R, Kopecek J, Proc. 13th Int. Symp. Cont. Rel. Biooac. Mater., 80 (1986)
  19. Pyser HJP, Shen WC, Proc. Natl. Acad. Sci., 75, 3867 (1978) 
  20. Petersen RV, Anderson JH, Fang SM, Feizen J, Gregonis DE, Kim SW, Polym. Prepr., 20, 20 (1979)
  21. Langer RS, Loise DL, Medical Application of Controlled Release, CRC Press, Florida (1984)
  22. Kim SW, Petersen R, Feizen J, Drug Design, 10, 193 (1980)
  23. Theeuwes F, "Controlled Release Technologies," A.F. Kydonieus Ed., CRC Press, p. 195 (1980)
  24. Theeuwes F, J. Pharm. Sci., 64, 1987 (1975) 
  25. Higuchi T, J. Pharm. Sci., 5, 874 (1961) 
  26. Hsieh DST, Ghine WD, Langer RS, J. Pharm. Sci., 72, 17 (1983) 
  27. Brooke D, Washkuhn RI, J. Pharm. Sci., 66, 159 (1977) 
  28. Lipper RA, Higuchi WI, J. Pharm. Sci., 66, 163 (1977) 
  29. Hopfenberg HB, "Controlled Release Polymeric Formulation," ACS Symponium Series No. 33, p. 26 (1976)
  30. Pedley DG, Shelly PJ, Tighe BJ, Br. Polym. J., 12, 99 (1980)
  31. Peppas NA, "Hydrogels in Medical and Pharmacy," CRC Press, Boca Raton, Vol. I ~ III (1987)
  32. Lee PI, Polymer, 25, 973 (1984) 
  33. Park H, Robinson JR, J. Control. Release, 2, 47 (1985) 
  34. Longer MA, Ching HS, Robinson JR, J. Pharm. Sci., 74, 406 (1988) 
  35. Svartz N, Acta. Med. Scand., 110, 55 (1942)
  36. Nakamura J, Shiota H, Haraguchi Y, Sasaki H, J. Pharm. Bio. Dyn., 11, 53 (1988)
  37. Brand JJ, Perry WLM, Pharmacol. Rev., 18, 895 (1966)
  38. Price NM, Schmitt LG, Mcguire J, Thorn D, Clin. Pharmacol. Ther., 29, 282 (1981)
  39. Garnier B, Imhof P, Spinelli F, Jost H, Schweiz. Rundsch. Med., 71, 511 (1982)
  40. Bridgman KM, Car M, Tattersall AB, J. Int. Med. Res., 12, 40 (1980)
  41. Arndts D, Arndts K, Eur. J. Clin. Pharmacol., 26, 79 (1984) 
  42. Popli S, Daugirdas JT, Norusis MJ, Hano JE, Gandhi VC, Clin. Ther., 5, 624 (1983)
  43. Nichols KC, Schenkel L, Benson H, Obstet Gynecol Surv., 39, 230 (1984) 
  44. Powers MS, Schenkel L, Dayley PE, Good WR, Bolestra JC, Am. J. Obstet. Gynecol., 152(8), 1099 (1984)
  45. Worthen DM, Zimmerman JJ, Wind CA, Invest. Opthal., 13, 296 (1974)
  46. Friedrich RL, Ann. Opthal., 6, 1279 (1974)
  47. Goodson JM, Offenbacher S, Farr DH, Hogan P, J. Perodontol., 52, 613 (1981)
  48. Dunn R, Lewis DH, Goodson JM, J. Dent. Res., 51, 274 (1982)