화학공학소재연구정보센터
Chemistry Letters, Vol.41, No.12, 1597-1599, 2012
Unexpected Extension of Usage of PPh3/CBr4, a Versatile Reagent: Isomerization of Aromatic Allylic Alcohols
The PPh3/CBr4-catalyzed isomerization of 2-aromatic allylic alcohols into the corresponding saturated aldehydes or ketones has been achieved at room temperature in good to excellent yields under mild and metal-free conditions. This new methodology has been applied successfully to the synthesis of ibuprofen in four steps.