화학공학소재연구정보센터
Biochemical and Biophysical Research Communications, Vol.430, No.1, 436-441, 2013
TNF alpha induced FOXP3-NF kappa B interaction dampens the tumor suppressor role of FOXP3 in gastric cancer cells
Controversial roles of FOXP3 in different cancers have been reported previously, while its role in gastric cancer is largely unknown. Here we found that FOXP3 is unexpectedly upregulated in some gastric cancer cells. To test whether increased FOXP3 remains the tumor suppressor role in gastric cancer as seen in other cancers, we test its function in cell proliferation both at basal and TNF alpha mimicked inflammatory condition. Compared with the proliferation inhibitory role observed in basal condition, FOXP3 is insufficient to inhibit the cell proliferation under TNF alpha treatment. Molecularly, we found that TNF alpha induced an interaction between FOXP3 and p65, which in turn drive the FOXP3 away from the promoter of the well known target p21. Our data here suggest that although FOXP3 is upregulated in gastric cancer, its tumor suppressor role has been dampened due to the inflammation environment. (C) 2012 Elsevier Inc. All rights reserved.