Journal of Chemical and Engineering Data, Vol.57, No.11, 3258-3263, 2012
Solubility and Induction Period Study of Asiaticoside and Madecassoside in a Methanol plus Water Mixture
The solubilities of madecassoside in a mixture of methanol + water were determined in the temperature range from (298.15 to 328.15) K by a static analytical method. A "W"-type curve was found for the solubility of madecassoside in the mixture of methanol + water. The induction periods of asiaticoside and madecassoside in a mixture of methanol + water were determined at 298.15 K by a laser scattering method. The results show that the solubilities of madecassoside are similar to those of asiaticoside in the mixture of methool-water excluding those at high water content and high temperature. However, these two compounds with the only difference of 6-OH exhibit a quite different crystallization property that the induction period of madecassoside is at least 10 times longer than asiaticoside. Moreover, the interfacial tension data of asiaticoside were obtained, which are in the range of (0.55 to 0.86) mJ.m(-2).