Particulate Science and Technology, Vol.29, No.3, 252-259, 2011
Fast Photolytic Release of Nano-Encapsulated Biocides for Neutralizing Bacteria
A fast-triggered photolytic technology based on the on-demand release of biocides encapsulated within phospholipid nanoparticles has been developed for the neutralization of biological contaminants such as bacteria. Fast-triggered release occurs when light sensitive molecules (photosensitizers) embedded within phospholipid particles are triggered by an external light stimulus. The photo-induced oxidation due to the stimulus causes the lipid chains to break and rapidly release their contents. When the phospholipid carriers are loaded with strong biocides, the fast-triggered release can result in the neutralization of biological contaminants in a controlled environment. It was observed that a 98% release of biocides was achieved in 12min and 68% release achieved in 2min through photo-induced oxidation. This method of release of biocides potentially can offer a technology for rapid decontamination inside heating, ventilation and air conditioning (HVAC) systems and surfaces such as walls, windows, etc. Moreover, biocide loaded phospholipid particles could be released as aerosols for neutralizing airborne bacteria and other biological contaminants. The appropriate choice of biocides can enable potential use in first-responder type situations and the automatic remote neutralization following bacterial contamination of air ducts or surfaces.