화학공학소재연구정보센터
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No. Article
1 Structure of the M2 muscarinic receptor-beta-arrestin complex in a lipid nanodisc
Staus DP, Hu HL, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G
Nature, 579(7798), 297, 2020
2 Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor
Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO
Science, 367(6480), 881, 2020
3 Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC
Science, 367(6480), 888, 2020
4 Mechanism of beta(2)AR regulation by an intracellular positive allosteric modulator
Liu XY, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B
Science, 364(6447), 1283, 2019
5 Mechanism of intracellular allosteric beta(2)AR antagonist revealed by X-ray crystal structure
Liu XY, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK
Nature, 548(7668), 480, 2017
6 Alfred Goodman Gilman (1941-2015) OBITUARY
Lefkowitz RJ
Nature, 529(7586), 284, 2016
7 Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ
Nature, 535(7612), 448, 2016
8 Visualization of arrestin recruitment by a G-protein-coupled receptor
Shukla AK, Westfield GH, Xiao KH, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi MJ, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL, Kobilka BK, Skiniotis G, Lefkowitz RJ
Nature, 512(7513), 218, 2014
9 A stress response pathway regulates DNA damage through beta(2)-adrenoreceptors and beta-arrestin-1
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao KH, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ
Nature, 477(7364), 349, 2011
10 beta-arrestin-dependent formation of beta(2) adrenergic receptor Src protein kinase complexes
Luttrell LM, Ferguson SSG, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin FT, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ
Science, 283(5402), 655, 1999