TY - JOUR PY - 2021 J2 - Biotechnol. Bioeng. SN - 0006-3592 T2 - Biotechnology and Bioengineering VL - 118 IS - 5 DO - 10.1002/bit.27716 TI - De novo sequence redesign of a functional Ras-binding domain globally inverted the surface charge distribution and led to extreme thermostability UR - https://www.cheric.org/research/tech/periodicals/view.php?seq=1859554 KW - epistasis KW - extremely thermostable protein KW - protein design KW - protein-fragment complementation assay KW - Ras-binding domain AU - Liu RC AU - Wang JC AU - Xiong P AU - Chen Q AU - Liu HY SP - 2031 EP - 2042 LA - English ER -