Research paperEvaluation of the bioadhesive properties of hyaluronan derivatives: Detachment weight and mucociliary transport rate studies
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Mucoadhesive properties of liquid lipid nanocapsules enhanced by hyaluronic acid
2019, Journal of Molecular LiquidsChitosan and hyaluronan coated liposomes for pulmonary administration of curcumin
2017, International Journal of PharmaceuticsCitation Excerpt :Surface modification of particles with chitosan has already been demonstrated to prolong their residence time in the airways in comparison with uncoated ones, thanks to ionic interactions between positive amino groups of the polymer and the negative mucus gel layer (Mura et al., 2011; Zaru et al., 2009). Besides, the negatively charged hyaluronic acid has also been extensively used to protect liposomes and enhance their mucohadesive properties (Lim et al., 2000; Pritchard et al., 1996). It is a natural non-toxic, biodegradable and non-immunogenic, polysaccharide composed of alternating d-glucuronic acid and N-acetyl-d-glucosamine repeating units (Dosio et al., 2016).
A focus on mucoadhesive polymers and their application in buccal dosage forms
2016, Journal of Drug Delivery Science and TechnologyCitation Excerpt :Moreover, it was also demonstrated that HA is able to enhance the penetration of drugs, such as acyclovir, in an extent comparable to chitosan hydrochloride [12]. The in vitro studies on mucoadhesive properties of ethyl and benzyl esters of HA evidenced that the esterification of the COOH groups reduces the adhesiveness of HA to mucosae since the ability of the macromolecules to form hydrogen bonds is reduced [49]. Compared to other linear mucoadhesive copolymers, HA exhibits a higher detachment work due to the HA/mucus interpenetration resulting in the strengthened mucus layer [50].
Comparison of functional and biological properties of chitosan and hyaluronic acid, to be used for the treatment of mucositis in cancer patients
2011, Journal of Drug Delivery Science and Technology