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Block copolymers of L-lactide and poly(ethylene glycol) for biomedical applications

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Poly (L-lactide)-poly (oxyethylene)-poly (L-lactide) block copolymers obtained in bulk, by a ring opening mechanism, from poly (ethylene glycol)s (PEG)s and L-lactide (LA), at 120–140°C, in the absence of added catalysts are described. By using PEGs with different molecular masses, 3000 and 35000, respectively, and varying the initial molar ratio LA to PEG, two series of copolymers with different molecular masses, relative length of blocks and hydrophilicity were obtained. Physico-chemical characterization of the copolymers had been previously performed. The morphological characteristics of the copolymers were investigated by means of X-ray diffractometry, optical and scanning electron microscopy. The biological properties of the materials were determined by evaluating their cytotoxicity, cytocompatibility, hemocompatibility and degradability using different standard tests. The results obtained indicate that the block copolymers synthesized may be useful for biomedical applications, in particular as resorbable drug vehicles. The materials are brittle and their mechanical properties are not appropriate for implant devices.

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References

  1. Y. KIMURA, V. MATSUZAKI, H. YAMANE and T. KITAO, Polymer 30 (1989) 1342.

    Google Scholar 

  2. X. M. DENG, C. D. XIONG, L. M. CHENG and R. P. XU, J. Polym. Sci. Polym. Lett. 28 (1990) 411.

    Google Scholar 

  3. K. J. ZHU, X. LIN and S. YANG, J. Appl. Polym. Sci. 39 (1990) 1.

    Google Scholar 

  4. H. R. KRICHELDORF and J. MEIER-HAACK, Makramal. Chem. 194 (1993) 463.

    Google Scholar 

  5. Z. JEDLINSKI, P. KURCOK, W. WALACH, H. JANECZEK and I. RADECKA, Makramal. Chem. 194 (1993) 1681.

    Google Scholar 

  6. R. SBARBATI DEL GUERRA, M. G. CASCONE, M. TRICOLI and P. CERRAI, Alternatives to Laboratory Animals 21 (1993) 907.

    Google Scholar 

  7. P. CERRAI, G. D. GUERRA, L. LELLI, M. TRICOLI, R. SBARBATI DEL GUERRA, M. G. CASCONE and P. GIUSTI, J. Mater. Sci. Mater. Med. 5 (1993) 33.

    Google Scholar 

  8. P. CERRAI and M. TRICOLI, Makromol. Chem., Rapid Comm. 14 (1993) 529.

    Google Scholar 

  9. P. GIUSTI, G. D. GUERRA, M. PALLA, G. SOLDANI, S. BONANNI and G. MAZZANTI, Progr. Biomed. Eng. 5 (Polym, Med, 3) (1988) 51.

    Google Scholar 

  10. G. D. GUERRA, N. BARBANI, L. LAZZERI, L. LELLI, M. PALLA and C. RIZZO, J. Biomat. Sci. Polymer Edn 4 (1993), 643.

    Google Scholar 

  11. U. CHRISTENSEN, Thromb, Haemostasis 43 (1980) 169.

    Google Scholar 

  12. P. CERRAI, M. TRICOLI, F. ANDRUZZI, M. PACI and M. PACI, Polymer 30 (1989) 338.

    Google Scholar 

  13. B. A. ROZENBERG, Makromol. Chem. Makromol. Symp. 60 (1992) 177.

    Google Scholar 

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Cerral, P., Tricoli, M., Lelli, L. et al. Block copolymers of L-lactide and poly(ethylene glycol) for biomedical applications. J Mater Sci: Mater Med 5, 308–313 (1994). https://doi.org/10.1007/BF00058953

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  • DOI: https://doi.org/10.1007/BF00058953

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