Biochemical and Biophysical Research Communications
Regular ArticleTwo Splice Variants of Human PEX19 Exhibit Distinct Functions in Peroxisomal Assembly☆
References (24)
- et al.
Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G
Am. J. Hum. Genet.
(2000) - et al.
Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p
Biochem. Biophys. Res. Commun.
(2000) - et al.
Identification and characterization of the human peroxin PEX3
Eur. J. Cell Biol.
(1999) - et al.
Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein
Genomics
(1997) Alternative splice variants of cytokines: Making a list
Life Sci.
(1997)- et al.
Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p
FEBS Lett.
(1998) - et al.
Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1
Gene
(1994) Components involved in peroxisome import, biogenesis, proliferation, turnover, and movement
Physiol. Rev.
(1998)- et al.
The life cycle of the peroxisome
Nat. Rev. Mol. Cell. Biol.
(2001) - et al.
Peroxisome biogenesis
Annu. Rev. Cell. Dev. Biol.
(2001)
Peroxisome synthesis in the absence of preexisting peroxisomes
J. Cell Biol.
Cited by (23)
Protein import machineries of peroxisomes
2011, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :The N-terminal domain is responsible for the membrane targeting of Pex19p as it mediates the interaction with the PMP Pex3p. The C-terminal domain harbors the binding sites for most PMPs [105–108]. The crystal structure of the folded C-terminal part of the receptor reveals a globular domain that binds PMP-targeting signal (mPTS) sequences.
Prenylated Proteins in Peroxisome Biogenesis
2011, EnzymesCitation Excerpt :The N-terminal domain is responsible for the membrane targeting of Pex19p as it mediates the interaction with Pex3p at the peroxisomal membrane. The C-terminal domain harbors the binding sites for most PMPs [51–54]. Crystal structure of the C-terminal part revealed that it consists of a bundle of three long helices in an antiparallel arrangement [55].
Farnesylation of Pex19p is required for its structural integrity and function in peroxisome biogenesis
2009, Journal of Biological ChemistryCitation Excerpt :In contrast to pex19Δ cells, the mutants still contained peroxisomes, indicating that the non-farnesylated Pex19p still maintained part of its function in peroxisome biogenesis. The PEX19-defective human cell line PBD399 represents complementation group 14 (complementation group J in Japan) and expresses a truncated version of Pex19p with a 44-amino acid deletion at the C terminus (11, 15, 26). This underscores the importance of the farnesylation motif, although it is unclear whether the truncated Pex19p is stably expressed in this patient cell line.
Peroxisome biogenesis disorders
2006, Biochimica et Biophysica Acta - Molecular Cell ResearchImport of peroxisomal membrane proteins: The interplay of Pex3p- and Pex19p-mediated interactions
2006, Biochimica et Biophysica Acta - Molecular Cell ResearchThe import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step
2006, Journal of Biological Chemistry
- ☆
Abbreviations used: ABC, half transporter ATP binding cassette transporter; ALDP, adrenoleukodystrophy protein; ALDRP, adrenoleukodystrophy related protein; GFP, green fluorescent protein; GST, glutathione-S-transferase; PEX, peroxisomal assembly protein; PMP70, 70-kDa peroxisomal membrane protein; PMP(s), peroxisomal membrane protein(s).
- 1
To whom correspondence and reprint requests should be addressed. Fax: +49 89 5160 3343. E-mail: [email protected].