Regular Article
Analysis of the Role of RecQ Helicases in RNAi in Mammals

https://doi.org/10.1006/bbrc.2002.6578Get rights and content

Abstract

The identity of mammalian genes involved in RNA interference (RNAi), the targeted sequence-specific mRNA degradation by double-stranded RNA (dsRNA), is poorly defined. Here we report the analysis of mice with null mutations of Wrn, Blm, and RecQ1 genes that are related to Mut-7 and Qde3, two genes essential for RNAi in Caenorhabditis elegans and quelling in Neurospora, respectively. Our results suggest that Wrn, Blm, and RecQ1 are not involved in sequence-specific mRNA degradation in mammals in response to dsRNA, suggesting potential differences in the mammalian RNAi pathway.

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1

These two authors contributed equally to this work.

2

To whom correspondence and reprint requests should be addressed at Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104-6018. Fax: (215) 898-8780. E-mail: [email protected].

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