Regular ArticleInhibition of the Ubiquitin-Proteasome Pathway Induces Differential Heat-Shock Protein Response in Cardiomyocytes and Renders Early Cardiac Protection
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Cited by (80)
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseDegradation systems in heart failure
2015, Journal of Molecular and Cellular CardiologyChronic aspirin via dose-dependent and selective inhibition of cardiac proteasome possibly contributed a potential risk to the ischemic heart
2013, Experimental GerontologyCitation Excerpt :One of the mechanisms is that the aberrant proteins caused by the inhibitor aggravated the ischemic cardiac dysfunction (Divald and Powell, 2006; Friguet and Szweda, 1997; Powell et al., 2005a, 2005b). Counterintuitively, some data argued that cardiac proteasome inhibition is cardioprotective to ischemic hearts (Drews et al., 2007; Hedhli et al., 2008; Huang et al., 2008; Pye et al., 2003; Stangl et al., 2002; Stansfield et al., 2007). The beneficial effects include significant reductions in cardiac infarct size, cardiomyocyte apoptosis, and myocardial hypertrophy, as well as preservation of ventricular functions and suppression of malignant ventricular arrhythmia.
Sodium arsenite and cadmium chloride induction of proteasomal inhibition and HSP accumulation in Xenopus laevis A6 kidney epithelial cells
2012, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCitation Excerpt :Previous studies have shown that inhibiting the activity of the proteasome leads to the accumulation of ubiquitinated proteins and an inhibition of proteasome chymotrypsin (CT)-like activity (Bush et al., 1997; Mimnaugh et al., 1997; Lee and Goldberg, 1998; Malik et al., 2001; Liao et al., 2006). Also, proteasomal inhibition has been reported to induce the accumulation of HSPs in a variety of eukaryotic model systems (Pritts et al., 2002; Stangl et al., 2002; `Le Goff et al., 2004; Awasthi and Wagner, 2005; Lundgren et al., 2005; Noonan et al., 2007; Walcott and Heikkila, 2010; Young and Heikkila, 2010; Khan and Heikkila, 2011). Xenopus laevis, the South African clawed frog, continues to be an important eukaryotic model system to study development as well as cellular and molecular biology.
Decreased heat shock protein 27 expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation
2011, MitochondrionCitation Excerpt :On the other hand, it is worthy to note that MG132 treatment increases Hsp27 expression in the murine lens epithelial cells and in oligodendroglial OLN-93 cells (Awasthi and Wagner, 2005; Bolhuis and Richter-Landsberg, 2010). However, MG132 treatment shows no effect on Hsp27 levels in neonatal rat cardiomyocytes or in human SK-N-SH cells (Chang et al., 2009; Stangl et al., 2002). These conflicting data of the levels of Hsp27 upon MG132 treatment suggest differential regulation of Hsp27 in different cell systems.
Curcumin-induced inhibition of proteasomal activity, enhanced HSP accumulation and the acquisition of thermotolerance in Xenopus laevis A6 cells
2011, Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
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