Biochemical and Biophysical Research Communications
Regular ArticleIdentification of Sonic Hedgehog-Responsive Genes Using cDNA Microarray
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Kruppel-Like Factor 4 represses osteoblast differentiation via ciliary Hedgehog signaling
2018, Experimental Cell ResearchCitation Excerpt :The reduction of Gli1 and slight induction of Ptch1 by KLF4 were also confirmed at the protein level (Fig. 2d). Since the evaluation by commonly used Hedgehog target gene expression was not conclusive, we analyzed Cyclin d2 (Ccnd2) which is another target gene [17]. Ccnd2 expression was repressed by KLF4 in osteoblasts (Fig. 2c).
Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes
2014, Experimental NeurologyCitation Excerpt :Therefore, these findings suggest the interesting potential that sepsis and NEC related decreases in IAIPs (Chaaban et al., 2009, 2010) may be associated with the development of inflammation-related brain injury in preterm infants (Shah et al., 2008; Stoll et al., 2004). In addition to the systemic link between IAIPs and inflammatory regulation following infection, IAIP related molecules and mRNA have been observed in neurons, astrocytes, and meningeal cells of the brain (Businaro et al., 1992; Chan et al., 1995; Daveau et al., 1998; Kato et al., 2001; Mizushima et al., 1998; Sanchez et al., 2002; Takano et al., 1999; Werbowetski-Ogilvie et al., 2006; Yoshida et al., 1991). Recent evidence also demonstrates decreases in the inter-alpha-trypsin inhibitor heavy chain 4 in the serum of human patients after acute ischemic stroke (Kashyap et al., 2009).
Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 in P19 cells
2005, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Microarray screening. cDNA microarray analysis was done as described previously [30]. Poly(A)+ RNAs were prepared by using Oligotex dT30 superkit according to the manufacturer’s instructions (TAKARA, Japan).
Purmorphamine induces osteogenesis by activation of the Hedgehog signaling pathway
2004, Chemistry and BiologyThe human prostate expresses Sonic hedgehog during fetal development
2002, Journal of Urology
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