Regular ArticleReactive Oxygen and NF-κB in VEGF-Induced Migration of Human Vascular Smooth Muscle Cells
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2021, Free Radical Biology and Medicinep66Shc regulates migration of castration-resistant prostate cancer cells
2018, Cellular SignallingCitation Excerpt :However, when ROS molecules are produced in excess, they also readily oxidize a number of cellular targets causing DNA, lipid, and protein damage, which facilitate various mutations and cancer development [16]. Furthermore, ROS is known to regulate processes like angiogenesis, cell adhesion, proliferation, and migration, all of which are critical to cancer metastasis [17–20]. Results of several studies have indicated oxidation of protein tyrosine phosphatases mediated by increased cellular levels of ROS can shown that cell migration in mouse fibroblasts [21,22].
High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation
2013, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :NADPH oxidase is a multicomponent protein formed by membrane-bound cytochrome b558 and composed of the catalytic subunits gp91phox and p22phox and cytosolic regulatory subunits comprised of p40phox, p47phox, p67phox and the small GTPase Rac [21,22]. ROS production is linked to VEGF expression in endothelial cells and in smooth muscle cells [23,24]. However, the mechanism of HG-induced ROS formation leading to VEGF production in synovial fibroblasts is, so far, unknown.
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