Regular ArticleA Novel Early Estrogen-Regulated Gene gec1 Encodes a Protein Related to GABARAP☆
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Solution structure of Atg8 reveals conformational polymorphism of the N-terminal domain
2010, Biochemical and Biophysical Research CommunicationsCitation Excerpt :To release Atg8 from the membrane Atg4 can also act as a deconjugation enzyme to regulate the Atg8 function during autophagosome formation. In addition to MAP LC3, three proteins have been identified as mammalian homologues of Atg8, including GABARAP (GABAA receptor-associated protein) [9], GEC1 (glandular epithelial cell protein 1) [10] and GATE-16 (Golgi-associated ATPase enhancer of 16 kDa) [11]. During the last years several structural studies using both, X-ray crystallography and nuclear magnetic resonance spectroscopy (NMR) were reported for MAP LC3, GABARAP, GEC1, and GATE-16 [12–21] as well as a crystal structure of Atg8G116 in complex with a peptide derived from Atg19 [22].
Expression of the GABA<inf>A</inf> receptor associated protein Gec1 is circadian and dependent upon the cellular clock machinery in GnRH secreting GnV-3 cells
2009, Molecular and Cellular EndocrinologySpecific regional distribution of gec1 mRNAs in adult rat central nervous system
2008, Brain ResearchCitation Excerpt :The gec1 mRNA is widely distributed in mouse, rat and human tissues. But, high expression levels have been observed in brain, heart, liver, skeletal muscle, kidney, placenta and peripheral blood leukocyte (Vernier-Magnin et al., 2001; Xin et al., 2001). Moreover, it has been demonstrated that gec1 is more expressed than gabarap in the human CNS, while gabarap is more expressed in endocrine glands (Nemos et al., 2003).
GEC1 interacts with the κ opioid receptor and enhances expression of the receptor
2006, Journal of Biological ChemistryCitation Excerpt :It is likely that the structure of GEC1 is similar to those of GATE-16 and GABARAP. The full-length GEC1 increased both cell-surface and total receptors of the hKOR to a much greater extent than GEC1-(38–117), indicating that the N-terminal region (1–37) of GEC1 binding to tubulin, hence microtubules, plays an important role in these increases. This observation is similar to that of Wang et al. (21) that the tubulin binding region of GABARAP is important for its stimulatory effect on clustering of GABAA receptors.
Strategy of macromolecular grafting onto a gold substrate dedicated to protein-protein interaction measurements
2006, Biosensors and BioelectronicsDistribution and ultrastructural localization of GEC1 in the rat CNS
2006, Neuroscience
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession Nos. AF 012920 (guinea-pig gec1 cDNA), AF 312680 (guinea-pig gec1 genomic DNA), and AF287012 (human GEC1 cDNA).
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