Regular ArticleCell-Type Specificity of l-Leucyl l-Leucine Methyl Ester
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Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin
2014, ImmunobiologyCitation Excerpt :These results suggest that LLME treatment killed monocytes and NK cells in PBMCs. It has been reported that LLME does not affect B cells derived from PBMCs (Kobayashi et al. 2000; Pecora et al. 1991). Thus, these results suggest that these cells removed by LLME treatment may suppress the immune response in PBMCs stimulated in vitro.
A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway
2011, Journal of Biological ChemistryCitation Excerpt :The reason for this differential sensitivity has not been fully clarified. Interestingly, however, many of the cell types that are susceptible to apoptosis via the lysosomal/granule pathway, e.g. NK cells, cytotoxic T lymphocytes, monocytes/macrophages (55, 56), and MCs (this study) are known to express high levels of SG (2). A possible explanation for the sensitivity of these cells to apoptosis could therefore be that they contain large amounts of intracellular SG.
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues
2008, Journal of Biological ChemistryCitation Excerpt :Essentially the same mechanism was observed in eight unrelated cell lines, including those of fibroblast, keratinocyte, hepatocyte, neuroblastoma, and breast cancer origin, suggesting that the mechanism used by LeuLeuOMe is likely highly conserved. The only distinction seems to be the different sensitivity of cells toward LeuLeuOMe, where NK cells and other bone marrow-derived cells were considerably more sensitive from the others (47-49) with no difference found between cancerous and noncancerous cell lines. Similar findings, i.e. LMP leading to MMP and subsequent caspase activation, were obtained by different lysosomotropic stimuli in different cellular models, such as by photodamage of murine hepatoma 1c1c7 cells (54), hydroxychloroquine, ciprofloxacin, or norfloxacin in HeLa and Jurkat cells and in various mouse embryonic fibroblasts (31, 35) and in reactive oxygen species-induced cell death in neutrophils in a model of bacteria infection (39).
In utero stem cell transplantation
2004, Best Practice and Research: Clinical Obstetrics and GynaecologySelective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins
2004, Journal of Biological ChemistryCitation Excerpt :Finally, lysosomal membrane integrity is lost, resulting in caspase activation and apoptosis (35). Various cells exhibit different sensitivity toward LeuLeuOMe, the most sensitive being the cytotoxic lymphocytes (36, 37). Because of their reasonably high content of Bid and various cathepsins including cathepsin C, we chose HeLa cells as a cellular model to investigate this process.
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