Regular ArticleRegulation and Significance of Hepatocyte-Derived Matrix Metalloproteinases in Liver Remodeling
References (37)
- et al.
Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration
Hepatology
(1995) - et al.
Extracellular matrix remodeling at the early stages of liver regeneration in the rat
Hepatology
(1997) - et al.
Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNF-α and TGF-β1
J. Hepatol.
(1999) - et al.
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells
J. Biol. Chem.
(1994) - et al.
Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells
J. Biol. Chem.
(1998) - et al.
Fibronectin-mediated cell adhesion is required for induction of 92-kDa type IV collagenase/gelatinase (MMP-9) gene expression during macrophase differentiation. The signaling role of protein kinase C-β
J. Biol. Chem.
(1998) - et al.
Hepatocyte growth factor-induced scatter of madin-darby canine kidney cells requires phosphatidylinositol 3-kinase
J. Biol. Chem.
(1995) - et al.
Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expression of c-jun and c-fos: Involvement of protein tyrosine kinase, protein kinase C, and Ca2+
Hepatology
(1996) - et al.
Phospholipase D mediates matrix metalloproteinase-9 secretion in phorbol ester-stimulated human fibrosarcoma cells
J. Biol. Chem.
(1999) - et al.
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
Proc. Natl. Acad. Sci. USA
(2000)
Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor
Cancer Res.
Collagenase pretreatment and the mitogenic effects of hepatocyte growth factor and transforming growth factor-a in adult rat liver
Hepatology
Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration
Hepatology
Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats
Hepatology
MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells
Hepatology
Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes
Am. J. Pathol.
Matrix metalloproteinase-2 activation in human hepatic fibrosis regulation by cell-matrix interactions
Hepatology
Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
Hepatology
Cited by (75)
Hepatocyte growth control by SOCS1 and SOCS3
2019, CytokineCitation Excerpt :Other matrix remodeling enzymes also influence the release of matrix-associated HGF following PH [115,134]. The induction of matrix metalloproteinase 9 (MMP9) by TNFα could also be responsible for its priming effect on liver regeneration via releasing HGF from the ECM [135,136]. The potential role of SOCS1 in regulating TLR signaling (discussed earlier) raises the possibility that SOCS1 may regulate hepatic HGF levels during liver regeneration.
Matrix metalloproteinases-9 deficiency impairs liver regeneration through epidermal growth factor receptor signaling in partial hepatectomy mice
2015, Journal of Surgical ResearchCitation Excerpt :Here we used MMP-9 KO mice to determine the impact of MMP-9 on EGFR signaling in liver regeneration after PH. Previous studies have reported that MMPs directly regulate liver regeneration through ECM remodeling [24,28,29]. ECM remodeling provides a beneficial microenvironment for regenerative cells, which is very important in the early stages of liver regeneration [12].
Matrix Metallopeptidase 9/Gelatinase B
2013, Handbook of Proteolytic EnzymesPotential role of caveolin-1 in acetaminophen-induced hepatotoxicity
2010, Toxicology and Applied PharmacologyA Critical Role for Matrix Metalloproteinases in Liver Regeneration
2008, Journal of Surgical ResearchCitation Excerpt :Because hepatic regeneration was inhibited by the administration of Marimastat, it appears that MMPs are critically important for organ regeneration in this partial hepatectomy model. MMPs may facilitate hepatic regeneration due to their direct effect on extracellular matrix remodeling, a process that is integral to tissue regeneration [26–28]. Alternatively, MMPs may influence the regenerative process indirectly, through their effects on angiogenesis.
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