Biochemical and Biophysical Research Communications
Mini ReviewSame causes, same cures
Section snippets
Portrait of dual fighters
First, since ROS is involved in the pathogenesis of AD and PDs [4], [5], antioxidants are expected to be of benefit for these diseases [6], [7], [8], [9]. Although convincing clinical evidence is still lacking, some modest therapeutic effects on AD and PDs have been observed for antioxidant combinations [7], [8], [9]. It is interesting to note that mixed tocopherols (vitamins E) are the common components in antioxidant prescriptions for AD and PDs [6], [7], [8], [9]. In addition, vitamin C,
Multipotency of dual fighters
Since multiple pathogenic factors are implicated in AD and PDs [1], [2], [3], [4], [5], the associated drug discovery paradigm is shifting from “one-drug, one-target” to “one-drug, multiple-targets”[37], [38], [39]. To fulfill the new strategy, one can resort to cocktails incorporating various compounds, such as antioxidants, nonsteroidal antiinflammatory drugs, cholinergic drugs, metal chelators, and amyloid inhibitors [6]. Alternatively, one can expect that one compound is endowed with
Conclusion
Similar causes underlying the pathogenesis of AD and PDs implicate that similar cures may exist for both kinds of diseases, which is well-illuminated by the presented dual fighters. Moreover, some super-dual-fighters may hit multiple targets implicated in AD and PDs, whose structural features highlight the importance of aromatic moiety and phenolic groups. These findings not only provide important clues to accelerating the screening of anti-AD and anti-PDs drugs but also help to understand the
Acknowledgments
This study was supported by the National Basic Research Program of China (Grant 2003CB114400) and the National Natural Science Foundation of China (Grants 30100035 and 30570383).
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