Abstract
This study aims to develop scaffold for transdermal drug delivery method (TDDM) using electrospinning technique from polyvinyl alcohol (PVA) and hydroxyethylcellulose (HEC). The fluorescein isothiocyanate (FITC) loaded on ethosomes (FITC@Eth) was used as a drug model. The prepared PVA/HEC/FITC@Eth scaffold was characterized via scanning electron microscope (SEM) that show morphology change by adding FITC@Eth. Also, Fourier transform infrared spectroscopy (FTIR), mechanical properties, X-ray diffraction (XRD), thermal gravimetric (TGA) analysis show that the addition of FITC@Eth to PVA/HEC does not change the scaffold properties. Franz diffusion cells were used for in vitro skin permeation experiments using rat dorsal skins. The FITC@Eth penetration was better than that of free FITC due to the presence of ethosome which enhance the potential skin targeting. In conclusion, the prepared PVA/HEC/FITC@Eth scaffold can serve as a promising transdermal scaffold for sustained FITC release.
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Funding
This research was supported by Shanghai Science and Technology Committee Project (18490740400), the Fundamental Research Funds for the Central Universities (2232019D3-20), the Project of Shaoxing Medical Key Discipline Construction Plan (NO. 2019SZD06), Opening project of Zhejiang provincial preponderant and characteristic subject of key university (traditional Chinese pharmacology), Zhejiang Chinese Medical University (ZYAOX2018035) and Project of Health and Family Planning Commission of Zhejiang province (2018KY831).
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El Fawal, G., Hong, H., Song, X. et al. Polyvinyl Alcohol/Hydroxyethylcellulose Containing Ethosomes as a Scaffold for Transdermal Drug Delivery Applications. Appl Biochem Biotechnol 191, 1624–1637 (2020). https://doi.org/10.1007/s12010-020-03282-1
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DOI: https://doi.org/10.1007/s12010-020-03282-1