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Preparation of electrospun core–sheath yarn with enhanced bioproperties for biomedical materials

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Abstract

Objectives

To create a multifunctional medical material that combines the advantages of both nanofibers and macroyarns.

Results

A novel electrospinning-based approach was developed for creating polycaprolactone (PCL) nanofiber covered yarns (PCL-NCYs) in which polyglycolic acid multi-strand filaments (PGA-MFs) were used as the core. BALB/3T3 (mouse embryonic fibroblast cell line) cells were cultured on the PCL-NCYs substrate and cell morphology and proliferation were determined by methylthiazol tetrazolium (MTT) assay. Compared with PGA-MFs, PCL-NCYs had a higher porosity and tensile strength of 88 ± 8% and 348 ± 16 MPa and in particular, the porosity was four times higher. BALB/3T3 cells attached more easily onto the nanofiber structure and proliferated along the direction of nanofibers, indicating that PCL-NCYs can achieve better cell differentiation and proliferation.

Conclusions

PCL-NCYs can be created by combining electrospinning covering and textile twisting, and have better mechanical property and higher porosity, and can be used as a novel scaffold in tissue engineering.

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Acknowledgements

This work was supported by grants from National Natural Science Foundation of China (51503168), Shaanxi Innovation Talent Promotion Program-Project for Youth New Star of Science and Technology (2017KJXX-23), Special Funding for Postdoctoral Innovation Project in Shandong Province (201504), Disciplinary Construction Fund for Textile Science and Engineering of Xi’an Polytechnic University (10709-0821), and Xi’an Polytechnic University Innovation Fund for Graduate Students (CX201729).

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Correspondence to Chengkun Liu.

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Li, B., Liu, C., Zhou, F. et al. Preparation of electrospun core–sheath yarn with enhanced bioproperties for biomedical materials. Biotechnol Lett 40, 279–284 (2018). https://doi.org/10.1007/s10529-017-2466-3

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  • DOI: https://doi.org/10.1007/s10529-017-2466-3

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