Journal of Industrial and Engineering Chemistry, Vol.46, 212-221, February, 2017
Synthesis/characterization of molecular imprinted polymer based on magnetic chitosan/graphene oxide for selective separation/ preconcentration of fluoxetine from environmental and biological samples
A novel molecular imprinted polymer (MIP) as a SPE sorbent was synthesized for fluoxetine through a coprecipitation method. The synthesized polymer was characterized by Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). The kinetic and adsorption equilibrium was studied. Quantification of fluoxetine was done based on the competitive inclusion complex formation of fluoxetine with phenolphthalein-β-cyclodextrin using fiber optic linear array spectrophotometry. The method exhibited a linear dynamic range of 0.8-10.0 μg L-1 with a detection limit of 0.03 μg L-1 and a preconcentration factor of 500. The developed method was successfully applied to determine fluoxetine in various samples.