화학공학소재연구정보센터
Journal of Industrial and Engineering Chemistry, Vol.46, 182-191, February, 2017
A unique scaffold for bone tissue engineering: An osteogenic combination of graphene oxide-hyaluronic acid.chitosan with simvastatin
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The present study explores the first ever fabrication of graphene oxide (GO)-Chitosan (CS)-Hyaluronic acid (HA) based bioactive composite scaffold containing an osteogenesis-inducing drug simvastatin (SV) for bone tissue engineering application. Porosity, density, swelling, degradation and biomineralization studies favored the SV loaded GO-CS-HA scaffold in comparison to the conventional CS and HA based scaffolds. The in vitro results showed that the SV also offers a significant influence on osteogenesis and biomineralization and it possess excellent biocompatibility to be used as a bone tissue engineering scaffold, which is able to persuade osteogenesis and mineralization.
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