화학공학소재연구정보센터
Polymer(Korea), Vol.40, No.2, 163-166, March, 2016
포르피린이 접목된 폴리아미노산 유도체를 이용한 자기조립체에 관한 연구
Biomimetic Self-assembly of Porphyrin-conjugated Polyaspartamide in Aqueous Solution
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초록
수용액상에서 다양한 형태를 갖는 자기조립 나노입자는 그 형태적 특이성으로 말미암아 표적지향 약물전달을 포함하여 다양한 응용분야에서 활발하게 연구되고 있다. 본 연구에서는 나노입자의 종횡비(aspect ratio)를 제어하는 새로운 자기조립 형성 기법을 확인하였다. 수용액상에서 자기조립 나노입자를 형성할 수 있는 포르피린이 접목된(grafted) 폴리아미노산 유도체를 합성하였다. 판상구조를 갖는 포르피린 분자의 접목도를 조절하여, 종횡비가 10 이상이 되는 막대형태의 자기조립 나노입자를 제조하였다. 포르피린이 도입된 자기조립나노입자는 산소분자를 선택적으로 포집할 수 있기 때문에 초음파 및 다양한 영상 진단을 위한 표적지향 전달체로 활용 될 수 있다.
Nano-sized self-assemblies with various morphologies are being extensively studied to use them in a variety of biological and industrial applications including targeted drug delivery. This study reports a novel strategy to prepare selfassemblies with high aspect ratio by varying packing structure. We synthesized poly(2-hydroxyethyl aspartamide) (PHEA) grafted with porphyrins, which could form self-assemblies in an aqueous solution. Then, increasing the degree of substitution of porphyrins induced the structural transition to rod-like assemblies with an aspect ratio of 10 by inter/intra molecular π-π stacking of porphyrins. Further introduction of metalloporphyrins to PHEA leads to an uptake of oxygen molecules. This strategy strategy to prepare polymer self-assemblies will serve to improve the efficiency of targeted delivery for a molecular optical and ultrasound imaging with various biomedical modalities.
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